Bayesian Integrative Genomics
Phase I: Funded by the BBSRC Exploiting Genomics initiative, from May 2002 to February 2007.
Phase II: A collaborative programme started in 2008, coordinated by Prof Sylvia Richardson.
Submitted publications
- Brown, A., Richardson, S., Whittaker, J., (2010) Application of the Lasso to expression Quantitative Trait Loci mapping, submitted, PDF abstract
- Papathomas, M., Dellaportas, P., Vasdekis, V. G. S. (2010) A novel proposal construction for reversible jump MCMC, PDF (to appear in Biometrika)
Invited papers
Richardson, S., Bottolo, L., Rosenthal, J. S. Bayesian models for sparse regression analysis of high dimensional data, paper, rejoinder.
Refereed journal publications
2011
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Turro E, Su S-Y, Goncalves A, Coin LJM, Richardson S and Lewin A (2011). Haplotype and isoform specific expression estimation using multi-mapping RNA-seq reads. Genome Biology. 12:R13. journal page.
2010
- Blangiardo M; Cassese A; Richardson S. (2010). sdef: an R package to synthesize lists of significant features in related experiments. BMC Bioinformatics. 11:270.journal page
- Bottolo L; Richardson S. (2010). Evolutionary Stochastic Search for Bayesian Model Exploration. BAYESIAN ANAL. 5:583-618. journal page.
- Papathomas M, Molitor J, Richardson S, Riboli E and Vineis P (2010), Examining the Joint Effect of Multiple Risk Factors Using Exposure Risk Profiles: Lung Cancer in Non-Smokers. Environmental Health Perspectives, journal page.
- Molitor J; Papathomas M; Jerrett M; Richardson S. (Jul 2010). Bayesian profile regression with an application to the National Survey of Children's Health. Biostatistics. 11:484-498, journal page
- Paige AJ; Zucknick M; Janczar S; Paul J; Mein CA; Taylor KJ; Stewart M; Gourley C; et al. (Mar 2010). WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis. Eur J Cancer. 46:818-825, jorunal page
- Petretto E; Bottolo L; Langley SR; Heinig M; McDermott-Roe C; Sarwar R; Pravenec M; Hubner N; et al. (Apr 2010). New insights into the genetic control of gene expression using a Bayesian multi-tissue approach. PLoS Comput Biol. 6:e1000737. journal page.
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Turro E, Lewin A, Rose A, Dallman M and Richardson S (2010), MMBGX: a method for estimating isoform and gene-level expression from whole transcript Affymetrix arrays that accounts for and exploits multi-match probes. Nucleic Acids Research Vol. 38, No. 1 e4. journal page
2009
- Broet P; Tan P; Alifano M; Camilleri-Broet S; Richardson S. (2009). Finding exclusively deleted or amplified genomic areas in lung cancer adenocarcinomas using a novel chromosomal pattern analysis. BMC Medical Genomics. 2:43. journal page
- Kulinskaya E and Lewin A (2009), On fuzzy familywise error rate and false discovery rate procedures for discrete distributions. Biometrika. 96:201-211. journal page
- Kulinskaya E and Lewin A (2009), Testing for linkage and Hardy-Weinberg disequilibrium. Ann Hum Genet. 73:253-262.
- Ratmann O; Andrieu C; Wiuf C; Richardson S. (30 Jun 2009). Model criticism based on likelihood-free inference, with an application to protein network evolution. Proc Natl Acad Sci U S A. 106:10576-10581.journal page
2008
- Blangiardo M; Richardson S. (2008). A Bayesian calibration model for combining different pre-processing methods in Affymetrix chips. BMC Bioinformatics. 9:512.journal page
- Zucknick, Manuela; Richardson, Sylvia; and Stronach, Euan A. (2008) "Comparing the Characteristics of Gene Expression Profiles Derived by Univariate and Multivariate Classification Methods" Statistical Applications in Genetics and Molecular Biology: Vol. 7 : Iss. 1, Article 7. journal page
2007
- Blangiardo M., Richardson S. (2007) Statistical tools for synthesizing lists of differentially expressed features in related experiments Genome Biology, 8, R54 journal page , with BGcom R package
- Bochkina N., Richardson S. (2007) Tail
posterior probability for inference in pairwise and multiclass gene expression
data, Biometrics, journal page, with supplementary material
- Lau, J. W. and Green P. J. (2007) Bayesian Model Based Clustering Procedures Journal of Computational and Graphical Statistics vol: 16 , Pages: 525 - 558, journal page
- Lewin, A., Bochkina, N. and Richardson, S (2007) Fully Bayesian mixture model for differential gene expression: simulations and model checks. Statistical Applications in Genetics and Molecular Biology Vol. 6 : Iss. 1, Article 36. journal page BGmix software
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Lewin, A., Richardson, S. (2007)
Bayesian methods for microarray data, to appear in the Handbook of Statistical Genetics, eds D. Balding, M. Bishop and C. Cannings, Wiley (draft PDF)
- Ratmann O; Jorgensen O; Hinkley T; Stumpf M; Richardson S; Wiuf C. (Nov 2007). Using likelihood-free inference to compare evolutionary dynamics of the protein networks of H. pylori and P. falciparum. PLOS COMPUT BIOL. 3:2266-2278, journal page
- Turro, E., Bochkina, N. Hein, A.-M.K., and Richardson, S. (2007)
BGX: a Bioconductor package for the Bayesian integrated analysis of
Affymetrix GeneChips, BMC Bioinformatics 2007, 8:439 (journal page).
2006
- Broët, P. and Richardson S. (2006), Detection of gene copy
number changes in CGH microarrays using a spatially correlated mixture model. Bioinformatics 2006 22(8):911-918; doi:10.1093/bioinformatics/btl035
journal page
supplementary
material
CGHmix WinBUGS code
- Hein, A.-M.K., Lewin, A. and Richardson, S. (2006)
Bayesian hierarchical models for inference in microarray data. In Do KA, Muller, P, and Vanucci M (eds).
Bayesian inference for gene expression and proteomics. Cambridge University Press. p. 53-70
- Hein A.-M. and Richardson S. (2006), A powerful method for detecting differentially expressed genes from GeneChip arrays that does not require replicates. BMC Bioinformatics 2006, 7:353 doi:10.1186/1471-2105-7-353
journal page
- Lewin, A. and Grieve, I. (2006), Grouping Gene Ontology terms to improve the assessment of gene set enrichment in microarray data. BMC Bioinformatics 2006 7:426 doi:10.1186/1471-2105-7-426
journal page
- Lewin, A., Richardson, S., Marshall, C., Glazier, A. and Aitman,
T. (2006), Bayesian Modelling of Differential Gene Expression.
Biometrics 2006 62: 10
doi:10.1111/j.1541-0420.2005.00394.x journal page supplementary
material, including WinBUGS code
2005
- Hein, A.-M.K., Richardson, S., Causton, H.C., Ambler, G.K., Green,
P.J. (2005), BGX: a fully Bayesian gene expression index for Affymetrix
GeneChip data. Biostatistics, 2005 6(3):349-373; doi:10.1093/biostatistics/kxi016. journal page
Software
2004
- Broët, P., Lewin, A., Richardson, S., Dalmasso, C. and Magdelenat,
H. (2004), A mixture model based strategy for selecting sets of genes in
multiclass response microarray experiments. Bioinformatics 2004
20(16):2562-2571; doi:10.1093/bioinformatics/bth285. journal
page journal
TOC software
2002
- Broët, P., Richardson, S. and Radvanyi, F. (2002), Bayesian
Hierarchical Model for Identifying Changes in Gene Expression from Microarray
Experiments Journal of Computational Biology 9, 671-683. journal
page
Technical reports and discussion contributions
- Richardson, S. (2010). Discussion of Meinshausen, N. and Buhlmann, P. Stablity selection. J ROY STAT SOC B. 72:448-451. publisher page
- Richardson, S. and Bottolo, L. (Nov 2008). Contribution to the discussion of Fan, J. and Lv, J. Sure independence screening for ultrahigh dimensional feature space. J ROY STAT SOC B. 70:891-892. publisher page